- Human pathology

Home > B. Cellular pathology > mitosis


Sunday 13 July 2003


- in a glandular epithelium

- in epidermis

- numerous atypical mitoses

Final steps

The final stages of mitosis begin in anaphase, when the mitotic spindle segregates the duplicated chromosomes. Mitotic exit is then completed by disassembly of the spindle and packaging of chromosomes into daughter nuclei.

The successful completion of mitosis requires that these events occur in a strict order. Two main mechanisms govern progression through late mitosis: dephosphorylation of cyclin-dependent kinase (Cdk) substrates and destruction of the substrates of the anaphase-promoting complex (APC).


- abnormal mitosis / abnormal mitoses
- high mitotic activity

See also

- mitotic spindle
- centrosomes
- cell cycle
- mitosis anomalies


- animal cell division

- plant cell division

- mitosis


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