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Home > G. Tumoral pathology > Molecular pathology of tumors > Genetic anomalies > Cancer cytogenetics > Tumoral translocations > t(14;18)(q32;q21)


Tuesday 8 March 2005

IGH-BCL2 rearrangement (IGH at 14q32 and BCL2 at 18q21)


- mature germinal center B-cell neoplasms

  • follicular lymphoma

See also

- t(2;18)(p11;q21) (IGK at 2p11 and BCL2 at 18q21)
- t(18;22)(q21;q11) (IGL at 22q11 and BCL2 at 18q21)
- Oncobase


- Combined molecular diagnosis of B-cell lymphomas with t(11;14)(q13;q32) or t(14;18)(q32;q21) using multiplex- and long distance inverse-polymerase chain reaction. Vieira L, Martinho A, Antunes O, Silva E, Ambrósio AP, Geraldes MC, Nascimento R, Silva C, Pereira JM, Júnior EC, Jordan P. Diagn Mol Pathol. 2008 Jun;17(2):73-81. PMID: 18382373

- Ruminy P, Jardin F, Penther D, Picquenot JM, Parmentier F, Buchonnet G, Bertrand P, Tilly H, Bastard C. Recurrent disruption of the Imu splice donor site in t(14;18) positive lymphomas : A potential molecular basis for aberrant downstream class switch recombination. Genes Chromosomes Cancer. 2007 Apr 23;46(8):735-744 PMID: 17455255