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systemic mastocytosis

Thursday 7 April 2005


- 6/M urticaria, Darier sign+; Metachromatic staining of granules by Giemsa.

- Mastocytosis of bones : woven bone


- c-kit-negative systemic mastocytosis (11446735)

See also

- mastocytoses

  • localized mastocytosis
    • solitary mastocytoma
    • cutaneous mastocytosis
  • systemic mastocytosis

- urticaria pigmentosa
- TMEP (telangiectasia macularis eruptiva perstans)


- A clinicopathologic study of 24 cases of systemic mastocytosis involving the gastrointestinal tract and assessment of mucosal mast cell density in irritable bowel syndrome and asymptomatic patients. Doyle LA, Sepehr GJ, Hamilton MJ, Akin C, Castells MC, Hornick JL. Am J Surg Pathol. 2014 Jun;38(6):832-43. doi : 10.1097/PAS.0000000000000190 PMID: 24618605 [Free on PMC]

- Systemic mastocytosis in 342 consecutive adults: survival studies and prognostic factors. Lim KH, Tefferi A, Lasho TL, Finke C, Patnaik M, Butterfield JH, McClure RF, Li CY, Pardanani A. Blood. 2009 Apr 10. PMID: 19363219

- Hahn HP, Hornick JL. Immunoreactivity for CD25 in gastrointestinal mucosal mast cells is specific for systemic mastocytosis. Am J Surg Pathol. 2007 Nov;31(11):1669-76. PMID: 18059223

- Complex karyotype and absence of mutation in the c-kit receptor in aggressive mastocytosis presenting with pelvic osteolysis, eosinophilia and brain damage. Jost E, Michaux L, Vanden Abeele M, Boland B, Latinne D, Godfraind C, Scheiff JM, Vaerman JL, Lecouvet F, Ferrant A. Ann Hematol. 2001 May;80(5):302-7. PMID: 11446735