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CASPs

Wednesday 16 July 2003

Caspases are a family of cysteine proteases that play a central role in apoptosis.

Caspases are highly conserved in multicellular organisms and function as central regulators of apoptosis.

In Caenorhabditis elegans, Drosophila and mice, caspases also function as regulatory molecules for immunity and cell-fate determination (nonapoptotic functions of caspases).

Members

CASP1 CASP2 CASP3 CASP4 CASP5 CASP6 CASP7 CASP8 CASP9 CASP10 CASP11

Pathology of caspases

- CASP8 and CASP10 mutations in autoimmune lymphoproliferative syndrome type 2 (ALPS2) (caspases-related ALPS)

  • CASP10 germline mutations in autoimmune lymphoproliferative syndrome type 2a (ALPS2a)
  • CASP8 germline mutations in autoimmune lymphoproliferative syndrome type 2b (ALPS2b)

See also

- autoimmune lymphoproliferative syndrome (ALPS)
- caspases pathway
- caspase inhibitors
- caspase substrates
- caspase-dependent cellular death

References

- Kuranaga E, Miura M. Nonapoptotic functions of caspases: caspases as regulatory molecules for immunity and cell-fate determination. Trends Cell Biol. 2007 Jan 31; PMID: 17275304

- Lavrik IN, Golks A, Krammer PH. Caspases: pharmacological manipulation of cell death. J Clin Invest. 2005 Oct;115(10):2665-72. PMID: 16200200

- Abraham MC, Shaham S. Death without caspases, caspases without death. Trends Cell Biol. 2004 Apr;14(4):184-93. PMID: 15066636

- Salvesen GS, Dixit VM: Caspases: intracellular signaling by proteolysis. Cell 91:443, 1997. PMID: 9390553