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giant cell hepatitis with autoimmune hemolytic anemia
Monday 13 June 2005
Autoimmune hemolytic anemia (AIHA) with giant cell hepatitis (GCH) is an uncommon disease in children and is associated with an aggressive and often fatal course.
Synopsis
autoimmune hemolytic anemia (AIHA)
post-infantile giant cell hepatitis
- diffuse giant cell hepatocyte transformation
- lobular architecture distortion
- portal inflammation
- portal fibrosis
- lobular pericellular fibrosis
- micronodular cirrhosis
hemophagocytosis (11345187)
Evans syndrome
Treatment
alemtuzumab (18030239)
rituximab (17460499)
cyclophosphamide (16266839)
liver transplantation (16176422)
See also
Hepatitis
- autoimmune hepatitis
- giant cell hepatitis
References
Autoimmune hemolytic anemia in an infant with giant cell hepatitis.
Kashyap R, Sarangi JN, Choudhry VP. Am J Hematol. 2006 Mar;81(3):199-201. PMID: 16493610
Giant cell hepatitis with autoimmune hemolytic anemia and hemophagocytosis. Hartman C, Berkowitz D, Brik R, Arad A, Elhasid R, Shamir R. J Pediatr Gastroenterol Nutr. 2001 Mar;32(3):330-4. PMID: 11345187
Perez-Atayde AR, Sirlin SM, Jonas M. Coombs-positive autoimmune hemolytic anemia and postinfantile giant cell hepatitis in children. Pediatr Pathol. 1994 Jan-Feb;14(1):69-77. PMID: 8159622
Bernard O, Hadchouel M, Scotto J, Odievre M, Alagille D. Severe giant cell hepatitis with autoimmune hemolytic anemia in early childhood. J Pediatr. 1981 Nov;99(5):704-11. PMID: 7299542
