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Home > G. Tumoral pathology > Molecular pathology of tumors > Genetic anomalies > Amplifications > Regional amplifications > amplicons


Wednesday 15 June 2005


- 1q21-q22 amplicon

- 12q13-12q14 amplicon

  • target genes: CDK4 (12q14)

- 15q25-26 amplicon

  • target genes: IGF1R


- Bignell GR, Santarius T, Pole JC, Butler AP, Perry J, Pleasance E, Greenman C, Menzies A, Taylor S, Edkins S, Campbell P, Quail M, Plumb B, Matthews L, McLay K, Edwards PA, Rogers J, Wooster R, Futreal PA, Stratton MR. Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution. Genome Res. 2007 Sep;17(9):1296-303. PMID: 17675364