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Clostridum botulinum

Thursday 25 August 2005

Pathology

- Botulinum neurotoxin serotype A (BoNT/A)

  • The toxins block neurotransmitter release by delivering their Zn(2+)-dependent protease components to the presynaptic side of chemical synapses.
  • These highly specialized enzymes exclusively hydrolyze peptide bonds within SNARE (soluble N-ethylmaleiamide-sensitive factor attachment protein receptor) proteins.

References

- Breidenbach MA, Brunger AT. New insights into clostridial neurotoxin-SNARE interactions. Trends Mol Med. 2005 Aug;11(8):377-81. PMID: 16006188