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clear cell hidradenoma

Friday 9 September 2005

clear cell variants of cutaneous hidradenomas, clear cell cutaneous hidradenoma


- Clear cell hidradenoma : dermal nodule with ducts, cuboidal cells with pink cytoplasm, and clear cell degeneration

Molecular biology

- TORC1-MAML2 fusion gene by t(11;19)(q21;p13)

  • fusion of the N-terminal CREB-binding domain of the cAMP coactivator TORC1 (a.k.a. MECT1 and WAMTP1) to the Notch coactivator MAML2.

See also

- dermal tumors


- Winnes M, Molne L, Suurkula M, Andren Y, Persson F, Enlund F, Stenman G. Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas. Genes Chromosomes Cancer. 2007 Jun;46(6):559-63. PMID: 17334997