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Saturday 19 July 2003

Telomere replication

Telomere replication relies on a strong synergy between the conventional replication machinery, telomere protection systems, DNA-damage-response pathways and chromosomal organization.


- telomeropathies
- telomere shortening
- telomere lengthening


- Telomeres at Kimball’s Biology Pages

See also

- telomere length
- shortening of telomeres (short telomeres)
- telomerases
- telomere maintenance
- telomere dysfunction
- telomere complexes
- telomeric associations
- telomere crisis
- telomere binding proteins


- Blasco MA. Telomeres and human disease: ageing, cancer and beyond. Nat Rev Genet. 2005 Aug;6(8):611-22. PMID: 16136653

- Stewart SA. Telomere maintenance and tumorigenesis: an "ALT"ernative road. Curr Mol Med. 2005 Mar;5(2):253-7. PMID: 15974880

- Opitz OG. Telomeres, telomerase and malignant transformation. Curr Mol Med. 2005 Mar;5(2):219-26. PMID: 15974876

- Greenberg RA. Telomeres, crisis and cancer. Curr Mol Med. 2005 Mar;5(2):213-8. PMID: 15974875

- Mason PJ, Wilson DB, Bessler M. Dyskeratosis congenita — a disease of dysfunctional telomere maintenance. Curr Mol Med. 2005 Mar;5(2):159-70. PMID: 15974869

- Wong JM, Collins K. Telomere maintenance and disease. Lancet. 2003 Sep 20;362(9388):983-8. PMID: 14511933

- Feldser DM, Hackett JA, Greider CW. Telomere dysfunction and the initiation of genome instability. Nat Rev Cancer. 2003 Aug;3(8):623-7. PMID: 12894250

- Hahn WC. Role of telomeres and telomerase in the pathogenesis of human cancer. J Clin Oncol. 2003 May 15;21(10):2034-43. PMID: 12743159

- Djojosubroto MW, Choi YS, Lee HW, Rudolph KL. Telomeres and telomerase in aging, regeneration and cancer. Mol Cells. 2003 Apr 30;15(2):164-75. PMID: 12803478

- Blasco MA. Telomerase beyond telomeres. Nat Rev Cancer. 2002 Aug;2(8):627-33. PMID: 12154355

- Cervantes RB, Lundblad V. Mechanisms of chromosome-end protection. Curr Opin Cell Biol. 2002 Jun;14(3):351-6. PMID: 12067658

- Tzukerman M, Selig S, Skorecki K. Telomeres and telomerase in human health and disease. J Pediatr Endocrinol Metab. 2002 Mar;15(3):229-40. PMID: 11924925

- Shay JW, Zou Y, Hiyama E, Wright WE. Telomerase and cancer. Hum Mol Genet. 2001 Apr;10(7):677-85. PMID: 11257099

- Marciniak RA, Johnson FB, Guarente L. Dyskeratosis congenita, telomeres and human ageing. Trends Genet. 2000 May;16(5):193-5. PMID: 10782108

- Royle NJ. Telomeres and disease. J Pathol. 1996 Nov;180(3):233-5. PMID: 8958797

Physiology references

- Gilson E, Géli V. How telomeres are replicated. Nat Rev Mol Cell Biol. 2007 Oct;8(10):825-38. PMID: 17885666

- Hahn WC. Telomere and telomerase dynamics in human cells. Curr Mol Med. 2005 Mar;5(2):227-31. PMID: 15974877

- Harley CB. Telomerase therapeutics for degenerative diseases. Curr Mol Med. 2005 Mar;5(2):205-11. PMID: 15974874

- von Zglinicki T, Martin-Ruiz CM. Telomeres as biomarkers for ageing and age-related diseases. Curr Mol Med. 2005 Mar;5(2):197-203. PMID: 15974873

- Beeharry N, Broccoli D. Telomere dynamics in response to chemotherapy. Curr Mol Med. 2005 Mar;5(2):187-96. PMID: 15974872

- Zimmermann S, Martens UM. Telomere dynamics in hematopoietic stem cells. Curr Mol Med. 2005 Mar;5(2):179-85. PMID: 15974871

- Boukamp P. Skin aging: a role for telomerase and telomere dynamics? Curr Mol Med. 2005 Mar;5(2):171-7. PMID: 15974870

- Chang S. Modeling premature aging syndromes with the telomerase knockout mouse. Curr Mol Med. 2005 Mar;5(2):153-8. PMID: 15974868

- Hezel AF, Bardeesy N, Maser RS. Telomere induced senescence: end game signaling. Curr Mol Med. 2005 Mar;5(2):145-52. PMID: 15974867

- Crabbe L, Karlseder J. In the end, it’s all structure. Curr Mol Med. 2005 Mar;5(2):135-43. PMID: 15974866

- Hande MP. DNA repair factors and telomere-chromosome integrity in mammalian cells. Cytogenet Genome Res. 2004;104(1-4):116-22. PMID: 15162024

- Mathieu N, Pirzio L, Freulet-Marriere MA, Desmaze C, Sabatier L. Telomeres and chromosomal instability. Cell Mol Life Sci. 2004 Mar;61(6):641-56. PMID: 15052408

- Shay JW, Wright WE. Telomeres are double-strand DNA breaks hidden from DNA damage responses. Mol Cell. 2004 May 21;14(4):420-1. PMID: 15149591

- Purdy A, Su TT. Telomeres: not all breaks are equal. Curr Biol. 2004 Aug 10;14(15):R613-4. PMID: 15296775

- Mefford HC, Trask BJ. The complex structure and dynamic evolution of human subtelomeres. Nat Rev Genet. 2002 Feb;3(2):91-102. PMID: 11836503

- Kipling D, Cooke HJ. Beginning or end? Telomere structure, genetics and biology. Hum Mol Genet. 1992 Apr;1(1):3-6. PMID: 1301133

- Blackburn EH: Switching and signaling at the telomere. Cell 106:661, 2001.