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giant cell angiofibroma

Tuesday 11 October 2005

Definition: Giant cell angiofibroma is a phenotypic variant of solitary fibrous tumor (SFT).

Giant cell angiofibroma seems most often to arise in the head and neck region (predominantly orbit) of adults and which, with the passage of time.

It may well prove to be a variant of solitary fibrous tumour characterized by prominent multinucleate giant cells and lipofibromatosis.

It is a rare tumour occurring predominantly in the hands or feet of infants and young children.

it shows a high rate of local recurrence and consists of a complex admixture of mature adipose tissue and a highly cellular, often primitive-looking fibroblastic component arranged in a septal distribution.


- orbital giant cell angiofibroma (18645449)
- oral giant cell angiofibroma (18758395)


- 6q13 rearrangements
- t(12;17)(q15;q23) (16527610)
- del(18)(q21) (16527610)


- Giant cell angiofibroma of the oral cavity: A case report and review of the literature. de Andrade CR, Lopes MA, de Almeida OP, León JE, Mistro F, Kignel S. Med Oral Patol Oral Cir Bucal. 2008 Sep 1;13(9):E540-3. PMID: 18758395

- Orbital giant cell angiofibroma recurring as a solitary fibrous tumor. Zoumalan CI, Egbert PR, Warwar RE, McCulley TJ. Ophthal Plast Reconstr Surg. 2008. Jul-Aug;24(4):325-7. PMID: 18645449

- The evolving classification of soft tissue tumours: an update based on the new WHO classification. Fletcher CD. Histopathology. 2006 Jan;48(1):3-12. PMID: 16359532

- A t(12;17) in an extraorbital giant cell angiofibroma. Qian YW, Malliah R, Lee HJ, Das K, Mirani N, Hameed M. Cancer Genet Cytogenet. 2006 Mar;165(2):157-60. PMID: 16527610