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Tuesday 11 October 2005

Definition: Myxofibrosarcoma (MFS) is one of the most common soft tissue sarcomas of elderly patients and has a predilection for the limbs.

Myxofibrosarcoma is the most common sarcoma of elderly patients is treated by complete surgical excision with negative margins.

Frequently elderly, extremities & superficial; progression from low-to-higher grade.


- FNA of Myxofibrosarcoma (MFS)

- Myxofibrosarcoma (MFS) : Myxofibrosarcoma has characteristic coarse curvilinear blood vessels (arrows) and cytologic atypia.

Digital slides

- JRC:71 : Soft tissue (shoulder): low-grade myxofibrosarcoma .

The term myxofibrosarcoma has been adopted for lesions formerly known as myxoid MFH. These lesions have been moved into the category of fibroblastic tumors.

Myxofibrosarcomas are a distinct and reproducible entity (quite separate from lesions formerly known as pleomorphic MFH), which represent the commonest type of soft tissue sarcoma in older adults.

Myxofibrosarcomas show a particular tendency to arise in subcutaneous tissue of the limbs and show a broad spectrum of morphological grade, but even the high-grade lesions, which may contain non-distinctive pleomorphic areas reminiscent of so-called MFH.

They have a metastatic rate of only approximately 35%, which is lower than most other types of pleomorphic sarcoma.


- epithelioid variant of myxofibrosarcoma (17197925)
- low-grade myxofibrosarcoma


- Highly complex karyotypes with extensive intratumoral heterogeneity have been reported. No consistent aberration.

See also

- myxoid tumors


- Nascimento AF, Bertoni F, Fletcher CD. Epithelioid Variant of Myxofibrosarcoma: Expanding the Clinicomorphologic Spectrum of Myxofibrosarcoma in a Series of 17 Cases. Am J Surg Pathol. 2007 Jan;31(1):99-105. PMID: 17197925