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FGFs

Wednesday 3 September 2003

Fibroblast growth factors (FGFs) comprise a family of related polypeptides with broad mitogenic and cell survival activities.

The fibroblast growth factor (FGF) family is comprised of 22 ligands that bind and activate several FGF receptor (FGFRs) isoforms.

Critical roles for FGFs and FGFRs have been well-established during embryonic development.

For example, the FGF10/FGFR2IIIb axis has been linked to embryonic development of both the mammary and prostate glands.

Mouse models have suggested that this pathway also participates in postnatal development in the mammary and prostate glands.

These studies have provided novel insights into the mechanisms by which FGFs and FGFRs promote ductal outgrowth and branching morphogenesis.

Members

FGF1 FGF2 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGF10
FGF11 FGF12 FGF13 FGF14 FGF15 FGF16 FGF17 FGF18 FGF19 FGF20
FGF21 FGF22 FGF23

Pathology

FGF3 - MIM.602115 - inner ear agenesis, microtia, and microdontia
FGF10 5p13-p12 MIM.602115 lacrimal gland aplasia
FGF10 5p13-p12 MIM.602115 salivary gland aplasia
FGF13 Xq26.3 MIM.300070
FGF14 13q34 MIM.601515 autosomal dominant cerebellar ataxia
FGF23 12p13.3 MIM.605380 autosomal dominant hypophosphatemic rickets MIM.193100

Oncogenesis

In addition to the established roles of FGFs in development, aberrant activation of the FGF pathway has been linked to tumor progression in both breast and prostate cancer.

Recent studies have linked FGFR1 expression and single nucleotide polymorphisms in FGFR2 to breast cancer. Furthermore, novel pre-clinical models have demonstrated the ability of FGFRs to promote numerous aspects of breast and prostate cancer.

See also

- FGF signaling
- FGFRs

References

- Fibroblast growth factors in development and cancer: insights from the mammary and prostate glands. Schwertfeger KL. Curr Drug Targets. 2009 Jul;10(7):632-44. PMID: 19601767

- Pauws E, Stanier P. FGF signalling and SUMO modification: new players in the aetiology of cleft lip and/or palate. Trends Genet. 2007 Dec;23(12):631-40. PMID: 17981355

- Lavine KJ, Ornitz DM. Fibroblast growth factors and Hedgehogs: at the heart of the epicardial signaling center. Trends Genet. 2008 Jan;24(1):33-40. PMID: 18054407

- Javerzat S, Auguste P, Bikfalvi A. The role of fibroblast growth factors in vascular development. Trends Mol Med. 2002 Oct;8(10):483-9. PMID: 12383771