Home > G. Tumoral pathology > small lymphocytic lymphoma
small lymphocytic lymphoma
Wednesday 2 November 2005
SLL; small cell lymphocytic lymphoma; SLL/CLL; Chronic lymphocytic leukemia and small lymphocytic lymphoma; CLL/SLL
AGCOH |
Chronic lymphocytic leukemia is a type of leukemia that mostly affects B-cell lymphocytes. Small lymphocytic lymphoma is also a cancer of the B-cell lymphocytes. B-cell chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are very similar diseases. They only differ in where the cancer occurs.
With CLL, the abnormal lymphocytes mainly affect the blood and bone marrow.
With SLL, the abnormal lymphocytes mainly affect the lymph nodes.
Images
bone marrow: SLL CD5+, CD23-, BCL1-, BCL2+
necrosis in CLL/SLL : HSV infection
Digital cases
HPC:348 : Pseudonodular lymphocytic lymphoma (chronic lymphocytic leukemia)
Synopsis
indolent disease
leukemic involvement by lymphoid cells, including prolymphocytes and/or paraimmunoblasts
splenomegaly
Immunochemistry
CD20+, CD5+, CD23+, CD10-
Pan-B+;
CD5+
CD23+
CD10-
sIgM+ faint
Differential diagnosis
diffuse small B-cell lymphomas
- mantle cell lymphoma
Putative cell of origin
CD5+ virgin B-cell with germline IgV genes
Cytogenetics
del(6)(q21-23) (20-30% of the cases)
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