small lymphocytic lymphoma

Chronic lymphocytic leukemia is a type of leukemia that mostly affects B-cell lymphocytes. Small lymphocytic lymphoma is also a cancer of the B-cell lymphocytes. B-cell chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are very similar diseases. They only differ in where the cancer occurs.

With CLL, the abnormal lymphocytes mainly affect the blood and bone marrow.
With SLL, the abnormal lymphocytes mainly affect the lymph nodes.

Images

 bone marrow: SLL CD5+, CD23-, BCL1-, BCL2+

• https://twitter.com/BellaMicheleang/status/777774807505072128

 necrosis in CLL/SLL : HSV infection

• https://twitter.com/mjcascio/status/857271286136885248

Digital cases

 HPC:348 : Pseudonodular lymphocytic lymphoma (chronic lymphocytic leukemia)

Synopsis

 indolent disease
 leukemic involvement by lymphoid cells, including prolymphocytes and/or paraimmunoblasts
 splenomegaly

Immunochemistry

 CD20+, CD5+, CD23+, CD10-
 Pan-B+;
 CD5+
 CD23+
 CD10-
 sIgM+ faint

Differential diagnosis

 diffuse small B-cell lymphomas

• mantle cell lymphoma

Putative cell of origin

 CD5+ virgin B-cell with germline IgV genes

Cytogenetics

 del(6)(q21-23) (20-30% of the cases)

Links

 AGCOH