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small lymphocytic lymphoma

Wednesday 2 November 2005

SLL; small cell lymphocytic lymphoma; SLL/CLL; Chronic lymphocytic leukemia and small lymphocytic lymphoma; CLL/SLL

AGCOH

Chronic lymphocytic leukemia is a type of leukemia that mostly affects B-cell lymphocytes. Small lymphocytic lymphoma is also a cancer of the B-cell lymphocytes. B-cell chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are very similar diseases. They only differ in where the cancer occurs.

With CLL, the abnormal lymphocytes mainly affect the blood and bone marrow.
With SLL, the abnormal lymphocytes mainly affect the lymph nodes.

Images

- bone marrow: SLL CD5+, CD23-, BCL1-, BCL2+

- necrosis in CLL/SLL : HSV infection

Digital cases

- HPC:348 : Pseudonodular lymphocytic lymphoma (chronic lymphocytic leukemia)

Synopsis

- indolent disease
- leukemic involvement by lymphoid cells, including prolymphocytes and/or paraimmunoblasts
- splenomegaly

Immunochemistry

- CD20+, CD5+, CD23+, CD10-
- Pan-B+;
- CD5+
- CD23+
- CD10-
- sIgM+ faint

Differential diagnosis

- diffuse small B-cell lymphomas

  • mantle cell lymphoma

Putative cell of origin

- CD5+ virgin B-cell with germline IgV genes

Cytogenetics

- del(6)(q21-23) (20-30% of the cases)

Links

- AGCOH