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fungal gastritis

Thursday 10 November 2005

Candida species, Histoplasma capsulatum, and Mucoraceae have been found in the stomach of immunocompromised subjects, particularly AIDS patients, with disseminated infections.

Endoscopically, gastric candidiasis appears as whitish patches scattered on the mucosa; microscopically, yeast forms are seen lying on and sometimes invading the eroded gastric mucosa.

Hyphae of Candida sp. may be found at the base of a large portion of gastric ulcers, but they are believed to represent the secondary colonization of preexisting peptic ulcers.

Histoplasmosis is diagnosed when the typical intracellular organisms are found within macrophages of the mucosa, which may be grossly intact, eroded, or ulcerated.

Gastric invasion by Mucormycosis agents, belonging to the Phycomycetes class, is rarely encountered and only in severely debilitated, immunocompromised patients.

The typical lesions consist of extensive hemorrhage and necrosis accompanied by an abundant inflammatory infiltrate but without granuloma formation.

Although the lesions are primarily mucosal, they can extend deeply into the wall and cause perforation.

Types

- Candida species (gastric candidiasis / Candida gastritis )
- Histoplasma capsulatum (gastric histoplasmosis )
- Mucoraceae (gastric zygomycosis )