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melanocytic nevi

Thursday 22 December 2005

melanocytic naevus; melanocytic naevi / nevus

PO

Types

- congenital melanocytic nevus
- melanocytic Spitz nevus
- deep-penetrating melanocytic nevus
- melanocytic combined nevus
- pigmented spindle cell nevus
- Halo nevus
- dysplastic melanocytic nevus
- melanocytic recurrent nevus
- melanocytic blue nevus

Images

- mitosis in melanocytic nevus

Molecular biology

- acquired melanocytic nevus : BRAF mutations
- congenital melanocytic nevus : NRAS mutations
- Spitz nevus / Spitz tumor / Spitzoid tumors : tyrosine kinase fusion

LOH

- 6q22-23.3 (29%)
- 1p36 (27%)
- 10q23 (25%
- 11q23 (10%)
- 8p22-24 (7%)

See also

- melanocytic tumors

  • malignant melanocytic tumors (melanoma)

References

- Loss of heterozygosity analysis of cutaneous melanoma and benign melanocytic nevi: laser capture microdissection demonstrates clonal genetic changes in acquired nevocellular nevi. Maitra A, Gazdar AF, Moore TO, Moore AY. Hum Pathol. 2002 Feb;33(2):191-7. PMID: 11957144