Humpath.com - Human pathology

Home > E. Pathology by systems > Digestive system > Liver and pancreatobiliary system > Liver > desmoplastic nested spindle cell tumor of liver

desmoplastic nested spindle cell tumor of liver

Wednesday 4 January 2006

Synopsis

- nested spindled and epithelioid cells with extensive desmoplasia
- well circumscribed, lobular white masses, ranging from 2.8 to 15 cm in diameter
- cohesive nests of plump, bland spindle cells arranged in short fascicles with an accompanying desmoplastic stroma
- epithelioid areas ranging from palisading epithelioid cells at the periphery of some nests to pseudoglandular and polygonal cells with intercellular bridges
- low mitotic activity
- calcification
- ossification
- non-neoplastic bile ducts and hepatic elements were seen both within and surrounding the tumor cell nests

Immunochemistry

- vimentin+
- pan-cytokeratin+
- CD57+
- WT1+ (nuclear staining)
- neuroendocrine markers negative

Ultrastructure

- focally well-developed cell junctions
- basal lamina
- few cytoplasmic organelles

References

- Hill DA, Swanson PE, Anderson K, Covinsky MH, Finn LS, Ruchelli ED, Nascimento AG, Langer JC, Minkes RK, McAlister W, Dehner LP. Desmoplastic nested spindle cell tumor of liver: report of four cases of a proposed new entity. Am J Surg Pathol. 2005 Jan;29(1):1-9. PMID: 15613851