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Home > G. Tumoral pathology > Molecular pathology of tumors > Genetic anomalies > Amplifications > Regional amplifications > 7q21 amplification

7q21 amplification

Thursday 5 January 2006


- glioblastoma multiforme (17002787)
- pediatric malignant astrocytoma (20068183)
- esophageal adenocarcinoma
- gastric adenocarcinomas (15623941)
- doxorubicin-resistant neuroblastoma (16450357)

Driver genes

- MDR1 in 7q21.11-13

Candidates genes

- CLDN12 (claudin-12) (MIM.611232)
- CDK6 in 7q21-q22 (MIM.603368)

See also

- regional amplifications
- genic amplification
- amplicons


- Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas. Schiffman JD, Hodgson JG, VandenBerg SR, Flaherty P, Polley MY, Yu M, Fisher PG, Rowitch DH, Ford JM, Berger MS, Ji H, Gutmann DH, James CD. Cancer Res. 2010 Jan 15;70(2):512-9. PMID: 20068183

- Ruano Y, Mollejo M, Ribalta T, Fiano C, Camacho FI, Gomez E, de Lope AR, Hernandez-Moneo JL, Martinez P, Melendez B. Identification of novel candidate target genes in amplicons of Glioblastoma multiforme tumors detected by expression and CGH microarray profiling. Mol Cancer. 2006 Sep 26;5:39. PMID: 17002787

- Flahaut M, Muhlethaler-Mottet A, Martinet D, Fattet S, Bourloud KB, Auderset K, Meier R, Schmutz NB, Delattre O, Joseph JM, Gross N. Molecular cytogenetic characterization of doxorubicin-resistant neuroblastoma cell lines: evidence that acquired multidrug resistance results from a unique large amplification of the 7q21 region. Genes Chromosomes Cancer. 2006 May;45(5):495-508. PMID: 16450357

- Wang YC, Juric D, Francisco B, Yu RX, Duran GE, Chen GK, Chen X, Sikic BI. Regional activation of chromosomal arm 7q with and without gene amplification in taxane-selected human ovarian cancer cell lines. Genes Chromosomes Cancer. 2005 Dec 28; PMID: 16382445

- Weiss MM, Kuipers EJ, Postma C, Snijders AM, Pinkel D, Meuwissen SG, Albertson D, Meijer GA. Genomic alterations in primary gastric adenocarcinomas correlate with clinicopathological characteristics and survival. Cell Oncol. 2004;26(5-6):307-17. PMID: 15623941