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persistent pulmonary hypertension of the newborn

Sunday 15 January 2006

Persistent pulmonary hypertension of the newborn (PPHN) is a life-threatening neonatal pathology resulting from poor hemodynamic and respiratory transition to extrauterine life.

Inhaled nitric oxide (iNO) is a current, commonly used treatment of PPHN. However, some infants with PPHN do not respond to iNO therapy. Because of the significant morbidity and mortality associated with PPHN, it is useful to look at other possible therapies, as sildenafil in the treatment of PPHN, either as a supplement to iNO or as an alternative to iNO.

See also

- persistent fetal circulation (PFC)
- neonatal pulmonary vascular diseases (NPVD)


- Impaired vascular endothelial growth factor signaling in the pathogenesis of neonatal pulmonary vascular disease. Abman SH. Adv Exp Med Biol. 2010;661:323-35. PMID: 20204740