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fetal thrombotic vasculopathy

Sunday 15 January 2006



Definition: Thrombi in the fetal circulation of the placenta cause a pattern of clustered fibrotic villi called fetal thrombotic vasculopathy (FTV), which has been associated with serious injuries to neonates, especially brain injuries.


- FTV - endothelial cushioning lesion and avascular villi


- fetal somatic thrombi (37.5%)

  • cerebral thrombi or infarcts (three cases)
  • renal thromboemboli (three cases)
  • pulmonary thromboemboli (two cases)

- severe perinatal liver disease

  • perinatal Budd-Chiari syndrome
    bile duct proliferation
    portal fibrosis

See also

- fetal thrombophilia
- inherited or acquired thrombophilic state


- Ariel I, Anteby E, Hamani Y, Redline RW. Placental pathology in fetal thrombophilia. Hum Pathol. 2004 Jun;35(6):729-33. PMID: 15188139

- Kraus FT, Acheen VI. Fetal thrombotic vasculopathy in the placenta: cerebral thrombi and infarcts, coagulopathies, and cerebral palsy. Hum Pathol. 1999 Jul;30(7):759-69. PMID: 10414494

- McDonald DG, Kelehan P, McMenamin JB, Gorman WA, Madden D, Tobbia IN, Mooney EE. Placental fetal thrombotic vasculopathy is associated with neonatal encephalopathy. Hum Pathol. 2004 Jul;35(7):875-80. PMID: 15257552

- Dahms BB, Boyd T, Redline RW. Severe perinatal liver disease associated with fetal thrombotic vasculopathy. Pediatr Dev Pathol. 2002 Jan-Feb;5(1):80-5. PMID: 11815872