- Human pathology

Home > D. General pathology > Therapy, Toxics and drugs > zidovudine


Thursday 27 January 2005

Nucleoside analogues can cause a mitochondrial myopathy with RRFs in muscle are nucleoside analogues, such as zidovudine, used in the treatment of certain human immunodeficiencies.

Nucleoside analogues, after conversion into their active form, inhibit mitochondrial DNA polymerase-gamma and induce mtDNA depletion.

See also

- nucleoside analogues
- mitochondrial diseases
- oxydative phosphorylation (OXPHOS system)