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Leydig cell tumor

Monday 13 February 2006

Leydig cell adenoma

Digital cases

- HPC:119 : Leydig cell tumor.
- JRC:18782 : Testis intestitial cell tumor


- Leydig cell tumor

- Reinke crystals in a Leydig cell tumour


- Leydig cell proliferation

  • round cell proliferation
  • fusiform cell proliferation

- Leydig cells

  • abundant eosinophilic cytoplasm
  • characteristic nuclear-rich zones separated by nuclear-free zones
  • crystals of Reinke (Reinke crystals)


- ovarian Leydig cell tumor
-  testicular Leydig cell tumor (Leydig cell tumor of the testis)

  • paratesticular Leydig cell tumor


- microcystic Leydig cell tumor (10328086)

Differential diagnosis

- yolk sac tumor (10328086)

See also

- Sertoli-stromal cell tumors


- Billings SD, Roth LM, Ulbright TM. Microcystic Leydig cell tumors mimicking yolk sac tumor: a report of four cases. Am J Surg Pathol. 1999 May;23(5):546-51. PMID: 10328086

- Leydig cell tumor of the testis: a clinicopathologic, DNA content, and MIB-1 comparison of nonmetastasizing and metastasizing tumors. Cheville JC, Sebo TJ, Lager DJ, Bostwick DG, Farrow GM. Am J Surg Pathol. 1998 Nov;22(11):1361-7. PMID: 9808128