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actute interstitial pneumonia

Friday 3 March 2006

AIP, Idiopathic DAD

Definition: Acute intersttitial pneumonia (AIP) is a clinical diagnosis that is made in patients presenting with ARDS of unknown cause (idiopathic) in whom the underlying lung lesion is determined by biopsy or autopsy to be diffuse alveolar damage (DAD).

Patients with AIP usually present with abrupt onset of dyspnea, cough, tachypnea and rapidly progressive respiratory failure often following a prodromal illness suggestive of an upper respiratory infection.

AIP is uncommon; the mortality rate is high.

Microscopic examination of lung tissue usually reveals DAD in its proliferative/organizing phase.

Remnants of hyaline membranes may be seen but are often not present.

AIP is considered to be similar if not equivalent to the Hamman-Rich syndrome.


- Acute interstitial pneumonia (AIP)/Idiopathic DAD at the Yale Rosen Collection


- Katzenstein AL, Myers JL, Mazur MT. Acute interstitial pneumonia. A clinicopathologic, ultrastructural, and cell kinetic study. Am J Surg Pathol. 1986 Apr;10(4):256-67. PMID: 3706612