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DCLAMP

MIM.605883 3q26.3-q27

Friday 3 March 2006

DC-LAMP is a novel lysosome-associated membrane glycoprotein.

Expression in normal cells

- Dendritic cell-lysosomal associated membrane protein (DC-LAMP)/CD208, a member of the lysosomal associated membrane protein (LAMP) family, is specifically expressed by human DCs on activation.

- DC-LAMP is constitutively expressed by mouse, sheep, and human type II pneumocytes.

  • Confocal and immunoelectron microscopy showed that mouse DC-LAMP protein co-localizes with lbm180, a specific marker for the limiting membrane of lamellar bodies that contain surfactant protein B, as well as with intracellular MHC class II molecules that accumulate in the same organelles.
  • Expression of DC-LAMP was also occasionally detected at the cell surface of type II pneumocytes.

Expression in tumors

- Bronchioloalveolar carcinoma tumor cells, which correspond to transformed type II pneumocytes, express DC-LAMP.

References

- Salaun B, de Saint-Vis B, Pacheco N, Pacheco Y, Riesler A, Isaac S, Leroux C, Clair-Moninot V, Pin JJ, Griffith J, Treilleux I, Goddard S, Davoust J, Kleijmeer M, Lebecque S. CD208/dendritic cell-lysosomal associated membrane protein is a marker of normal and transformed type II pneumocytes. Am J Pathol. 2004 Mar;164(3):861-71. PMID: 14982840