Humpath.com - Human pathology

Home > D. General pathology > Genetic and developmental anomalies > X-linked dominant diseases

X-linked dominant diseases

Saturday 11 March 2006

Definition: X-linked dominant disease are caused by mutations in genes on the X chromosome. Only a few disease have this inheritance pattern.

Females are more frequently affected than males, and the chance of passing on an X-linked dominant disease differs between men and women.

The sons of a man with an X-linked dominant disease will not be affected, and his daughters will all inherit the condition. A woman with an X-linked dominant disease has a 50% chance of having an affected daughter or son with each pregnancy.

Some X-linked dominant conditions, such as Aicardi syndrome, are fatal to boys, therefore only girls have them (and boys with Klinefelter syndrome).

See also

- genetic diseases

  • genic diseases