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Home > D. General pathology > Therapy, Toxics and drugs > etoposide


Sunday 12 March 2006

Etoposide is a semisynthetic derivative of the podophyllotoxins, an epipodophyllotoxin. It inhibits DNA topoisomerase II, thereby inhibiting DNA synthesis.

Etoposide is cell cycle dependent and phase specific, affecting mainly the S and G2 phases.