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carboplatin

Sunday 12 March 2006

Definition: Carboplatin is an analog of cisplatin.

- Like cisplatin, it contains a platinum atom surrounded in a plane by two ammonia groups and two other ligands in the cis position. The other two ligands in carboplatin are present in a ring structure rather than as two chloride atoms in cisplatin. This difference makes carboplatin more stable and has less nephrotoxicity, neurotoxicity, ototoxicity and emetogenesis.

- The exact mechanism of action of carboplatin is not known. Carboplatin undergoes intracellular activation to form reactive platinum complexes which are believed to inhibit DNA synthesis by forming interstrand and intrastrand cross-linking of DNA molecules. Carboplatin is a radiation-sensitizing agent. It is cell cycle-phase nonspecific.