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vincristin

Sunday 12 March 2006

Vincristine is a naturally occurring vinca alkaloid.

Vinca alkaloids act as antimicrotubule agents that block mitosis by arresting cells in the metaphase.These drugs act by preventing the polymerization of tubulin to form microtubules, as well as inducing depolymerization of formed tubules. Vinca alkaloids are cell cycle phase-specific for M phase and S phase.