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Home > D. General pathology > Pathogenic agents > carmustin


Sunday 12 March 2006

Carmustine is a highly lipophilic nitrosourea compound which undergoes hydrolysis in vivo to form reactive metabolites. These metabolites cause alkylation and cross-linking of DNA.

Other biologic effects include inhibition of DNA repair and some cell cycle phase-specificity. Nitrosoureas generally lack cross-resistance with other alkylating agents.

See also

- nitrosoureas
- alkylating agents