Humpath.com - Human pathology

Home > D. General pathology > Therapy, Toxics and drugs > streptozocin

streptozocin

Sunday 12 March 2006

Streptozocin is an antitumour antibiotic consisting of a nitrosourea moiety interposed between a methyl group and a glucosamine.

Although its mechanism of action is not completely clear, streptozocin is known to inhibit DNA synthesis, interfere with biochemical reactions of NAD and NADH, and inhibit some enzymes involved in gluconeogenesis.

Streptozocin is cell cycle phase-nonspecific and non-cross-resistant with other nitrosoureas.