Molecular processes

Articles

• cellular stress
  2 December 2003

  Stress to the cell causes protein denaturation: the protein molecule loses its native functional conformation when it unfolds. Chaperones assist the damaged molecule to regain its functional conformation.
  If cellular stress proceeds unchecked by such antistress mechanisms as the protein-refolding action of chaperones, intracellular proteins become denatured and insoluble.
  These denatured proteins tend to stick to one another, precipitate, and form inclusion bodies. The development of (...)

• DNA recombination
  13 July 2003

  References
  Kauppi L, Jeffreys AJ, Keeney S. Where the crossovers are: recombination distributions in mammals. nNat Rev Genet. 2004 Jun;5(6):413-24. PMID: #15153994#
  Stumpf MP, McVean GA. Estimating recombination rates from population-genetic data. Nat Rev Genet. 2003 Dec;4(12):959-68. PMID: #14631356#
  Koehler KE, Hawley RS, Sherman S, Hassold T. Recombination and nondisjunction in humans and flies. Hum Mol Genet. 1996;5 Spec No:1495-504. PMID: (...)

• antibody class switching
  19 August 2004

  References
  Kaminski DA, Stavnezer J. Antibody class switching: uncoupling S region accessibility from transcription. Trends Genet. 2004 Aug;20(8):337-40. PMID: #15262403#

• chromatin remodeling
  29 October 2003

  chromatin remodelling, chromatin-remodeling

• extracellular proteolysis
  14 April 2004

  References
  Madani R, Nef S, Vassalli JD. Emotions are building up in the field of extracellular proteolysis. Trends Mol Med. 2003 May;9(5):183-5. PMID: #12763521#

• exonic skipping
  14 April 2004

  exon skipping

• protein carbonylation
  14 April 2004

  See also
  carbonyl group
  References
  Dalle-Donne I, Giustarini D, Colombo R, Rossi R, Milzani A. Protein carbonylation in human diseases. Trends Mol Med. 2003 Apr;9(4):169-76. PMID: #12727143#

• S-nitrosylation
  14 April 2004

  S-nitrosylation is a ubiquitous redox-related modification of cysteine thiol by nitric oxide (NO), which transduces NO bioactivity. Accumulating evidence suggests that the products of S-nitrosylation, S-nitrosothiols (SNOs), play key roles in human health and disease.
  Feature
  nitric oxide metabolism
  References
  Foster MW, McMahon TJ, Stamler JS. S-nitrosylation in health and disease. Trends Mol Med. 2003 Apr;9(4):160-8. PMID: (...)

• transcription-coupled NER
  26 March 2006

  TCNER, transcription-coupled nucleotide excision repair, transcription coupled repair (TCR)

• DNA fragmentation
  2 December 2003

  References
  Zhang J, Xu M. Apoptotic DNA fragmentation and tissue homeostasis. Trends Cell Biol. 2002 Feb;12(2):84-9. PMID: #11849972#

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