Dysimmune diseases

Articles

• dermatitis herpetiformis
  29 June 2004

  herpetiform dermatitis
  Definition: Dermatitis herpetiformis is characterized by papules, vesicles, and occasional bullae on an erythematous, often urticarial base.
  Dermatitis herpetiformis is associated with gluten-sensitive enteropathy. It causes small pruritic vesicles.
  Histologically it shows papillary neutrophilic microabscesses and a mixed dermal inflammatory infiltrate. DIF shows a granular pattern of IgA in the dermal papillae.
  Digital cases
  UI:924 - Dermatitis herpetiformis (...)

• atopic dermatitis
  12 May 2005

  Susceptibility SNPs
  rs479844 upstream of OVOL1
  rs2164983 near ACTL9 (proliferation and differentiation)
  rs2897442 in KIF3A within the cytokine cluster at 5q31.1
  FLG locus
  11q13.5
  20q13.33
  Reviews
  Williams HC. Clinical practice. Atopic dermatitis. N Engl J Med. 2005 Jun 2;352(22):2314-24. PMID: #15930422#
  Bowcock AM, Cookson WO. The genetics of psoriasis, psoriatic arthritis and atopic dermatitis. Hum Mol Genet. 2004 Apr 1;13 Spec No 1:R43-55. PMID: #14996755#
  Galli E, (...)

• celiac disease
  6 April 2004

  coeliac disease; celiac sprue; gluten-sensitive enteropathy
  Definition: Celiac disease is a common autoimmune condition triggered by ingesting one of several related proteins found in wheat, barley, and rye: the gliadins, hordeins, and secalins.
  In susceptible persons, ingestion of these proteins leads to infiltration of the intestinal mucosa by both intraepithelial CD8+ lymphocytes and CD4+ lamina propria lymphocytes and, ultimately, to crypt hyperplasia and villous atrophy.
  Symptoms (...)

• giant cell hepatitis with autoimmune hemolytic anemia
  13 June 2005

  Coombs positive giant cell hepatitis, GCHAIHA

• IPEX syndrome
  12 November 2003

  Definition: IPEX is a X-inked fatal disorder characterized by immune dysregulation, polyendocrinopathy, enteropathy and X-linked inheritance (MIM.304930).
  Patients typically present in infancy with severe diarrhea and failure to thrive. Most children die by 1 year of age without therapy. The diagnosis is established by genetic analysis, which often takes several weeks to complete and can sometimes delay crucial immunosuppressive treatment.
  Synopsis
  dysimmune enteropathy (autoimmune (...)

• APECED
  21 November 2003

  Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED); autoimmune polyendocrine syndrome type I; autoimmune polyendocrinopathy syndrome type I; APS1; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy
  Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare autosomal recessive disorder defined by the presence of two of three conditions, namely, Addison’s disease, hypoparathyroidism, and mucocutaneous candidiasis.
  Autoimmune (...)

• antiphospholipid syndrome
  25 October 2004

  Definition: The antiphospholipid syndrome is characterized by clinical evidence of arterial or venous thrombosis, thrombocytopaenia, recurrent fetal loss and repeated positivity of antiphospholipid autoantibodies.
  The designation ’antiphospholipid syndrome’ was proposed for the association of arterial and venous thrombosis, recurrent fetal loss, and immune thrombocytopenia with a spectrum of autoantibodies directed against cellular phospholipid components.
  Anticardiolipin antibodies may (...)

• microscopic polyarteritis
  18 November 2003

  hypersensitivity vasculitis, microscopic polyangiitis

• autoimmune polyglandular syndrome type 1
  16 November 2007

  autoimmune polyglandular syndrome type I, APS1, APECED

• idiopathic thrombopenic purpura
  4 April 2006

  Digital case
  HPC:300 : Normal spleen (Idiopathic thrombopenic purpura)
  See also
  purpura

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