Cellular functions

Articles

• genomic stability
  13 July 2003

  A fundamental axiom of genetic inheritance is a requirement for exceptional genetic stability over many generations of cells and organisms. However, cells have to contend with both intracellular and extracellular environments that constantly challenge the chemical stability of the genome.
  Additionally, although normal metabolic transactions of DNA such as replication, recombination and repair are generally highly accurate, there are limits to the fidelity of these processes, so genomic (...)

• nucleocytoplasmic transport
  2 December 2003

  References
  Kuersten S, Ohno M, Mattaj IW. Nucleocytoplasmic transport: Ran, beta and beyond. Trends Cell Biol. 2001 Dec;11(12):497-503. PMID: #11719056#

• proteolysis
  19 July 2003

  Types
  ubiquitin-independent proteolysis
  ubiquitin-dependent proteolysis
  Pathology of proteolysis
  Anomalies of proteases genes (53 human diseases are caused by mutations in protease genes)
  nonsyndromic deafness (transmembrane serine protease TMPRSS3)
  early-onset familial Alzheimer’s disease (presenilin-1 PSEN1 and presenilin-2 PSEN2)
  pycnodysostosis (cathepsin-K CTSK) (MIM.265800)
  Papillon-Lefevre and Haim-Munk syndrome (MIM.245000)
  limb-girdle muscular dystrophy type 2A (...)

• vesicle-mediated sorting of proteins
  25 September 2003

  Pathology
  mutations in COH1 in Cohen syndrome (#12730828#)

• DNA repair
  13 July 2003

  DNA reparation, DNA damage response, gene repair

• immune cell interactions
  28 December 2004

  immune-cell interactions

• endocytosis
  16 September 2003

  endocytic pathway, endocytic trafficking

• cell survival
  10 November 2003

  cellular survival

• cellular interactions
  10 July 2003

  Types
  immune-cell interactions
  Pathology of cellular interactions
  References
  Friedl P, Storim J. Diversity in immune-cell interactions: states and functions of the immunological synapse. Trends Cell Biol. 2004 Oct;14(10):557-67. PMID: #15450978#

• extracellular matrix remodeling
  11 July 2003

  References
  Stamenkovic I. Extracellular matrix remodelling: the role of matrix metalloproteinases. J Pathol. 2003 Jul;200(4):448-64. PMID: #12845612#

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