Functional proteic groups

Articles

• chaperonins
  23 November 2003

  Chaperonins are multisubunit, cylinder-shaped molecular chaperones involved in folding newly synthesized polypeptides.
  Chaperonins are key components of the cellular chaperone machinery. These large, cylindrical complexes contain a central cavity that binds to unfolded polypeptides and sequesters them from the cellular environment. Substrate folding then occurs in this central cavity in an ATP-dependent manner.
  The eukaryotic chaperonin TCP-1 ring complex (TRiC, also called CCT) is (...)

• anion transporters
  21 November 2003

  Pathology
  diastrophic dysplasia
  congenital chloride diarrhoea
  Pendred syndrome
  References
  Everett LA, Green ED. A family of mammalian anion transporters and their involvement in human genetic diseases. Hum Mol Genet. 1999;8(10):1883-91. PMID: #10469841#

• ERM proteins
  6 February 2006

  ERM proteins (Ezrin-Radixin-Moesin proteins)
  Ezrin (VIL2), radixin (RDX) (MIM.179410), and moesin (MSN) (MIM.309845), the so-called ERM proteins (Ezrin-Radixin-Moesin proteins), act as linkers between the plasma membrane and the actin cytoskeleton.
  ERM proteins are involved in a variety of cellular functions, such as cell adhesion, cell migration, and the organization of cell surface structures. ERM proteins are highly homologous, both in protein structure and in functional activity, (...)

• bacterial toxins
  12 November 2003

  References
  Lax AJ. New genotoxin shows diversity of bacterial attack mechanisms. Trends Mol Med. 2007 Jan 16; PMID: #17234453#
  Fasano A. Toxins and the gut: role in human disease. Gut. 2002 May;50 Suppl 3:III9-14. PMID: #11953326#

• voltage-gated ion channel
  26 January 2005

  voltage-gated ion channels

• adaptator proteins
  16 July 2004

  adaptators

• cytoskeletal polymers
  18 February 2005

  Types
  microtubules
  actins
  neurofilaments
  Animations
  Axonal transport: A movie from J Cell Biol

• small GTPases
  30 November 2003

  small GTPases of the Ras superfamily in epithelial biogenesis
  The small GTPases of the Ras superfamily play critical roles in epithelial biogenesis. Many key morphogenetic functions occur when small GTPases act at epithelial junctions, where they mediate an increasingly complex interplay between cell-cell adhesion molecules and fundamental cellular processes, such as cytoskeletal activity, polarity and trafficking.
  Important recent advances in this field include the role of additional (...)

• DNA methyltransferases
  21 November 2003

  Patterns of DNA methylation are laid out during early embryogenesis via the interplay of at least three active DNA methyltransferases, DNMT1, DNMT3A, and DNMT3B, and targeted deletions of these genes in the mouse have demonstrated that the enzymes are essential for normal development.
  DNMT1 associates with the DNA replication fork and functions as a hemi-methylase responsible for maintaining correct methylation patterns on DNA replication. DNMT3s (DNMT3A and DNMT3B) are instead de novo (...)

• morphogens
  29 October 2003

  morphogen gradients

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