Chemotactic cytokines
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Functional proteic groups
Articles
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chemokines
18 November 2003 -
HDACs
23 November 2003histone deacetylases
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growth factor receptors
21 November 2003References
Leof EB. Growth factor receptor signalling: location, location, location. Trends Cell Biol. 2000 Aug;10(8):343-8. PMID: #10884687# -
oncogenes
29 October 2003Pathology
activation mutation
overexpression
fusion gene in which the promoter region of genes coding for the subunits of immunoglobulins (IGHG1, IGLC1, IGKC) or TCR (TCRA, TCRB, TCRC, TCRD) are juxtaposed to the entire coding sequence of a second gene that is subsequently overexpressed in lymphoid cells causing lymphomas or lymphoid leukemias
fusion gene in which the promoter region of a first gene is juxtaposed to the entire coding sequence of a second gene that is subsequently (...) -
nuclear hormone receptors
23 November 2003NHRs
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chaperonins
23 November 2003Chaperonins are multisubunit, cylinder-shaped molecular chaperones involved in folding newly synthesized polypeptides.
Chaperonins are key components of the cellular chaperone machinery. These large, cylindrical complexes contain a central cavity that binds to unfolded polypeptides and sequesters them from the cellular environment. Substrate folding then occurs in this central cavity in an ATP-dependent manner.
The eukaryotic chaperonin TCP-1 ring complex (TRiC, also called CCT) is (...) -
anion transporters
21 November 2003Pathology
diastrophic dysplasia
congenital chloride diarrhoea
Pendred syndrome
References
Everett LA, Green ED. A family of mammalian anion transporters and their involvement in human genetic diseases. Hum Mol Genet. 1999;8(10):1883-91. PMID: #10469841# -
odorant receptors
23 November 2003References
Kratz E, Dugas JC, Ngai J. Odorant receptor gene regulation: implications from genomic organization. Trends Genet. 2002 Jan;18(1):29-34. PMID: #11750698# -
DNA methyltransferases
21 November 2003Patterns of DNA methylation are laid out during early embryogenesis via the interplay of at least three active DNA methyltransferases, DNMT1, DNMT3A, and DNMT3B, and targeted deletions of these genes in the mouse have demonstrated that the enzymes are essential for normal development.
DNMT1 associates with the DNA replication fork and functions as a hemi-methylase responsible for maintaining correct methylation patterns on DNA replication. DNMT3s (DNMT3A and DNMT3B) are instead de novo (...) -
protein phosphatases
1 December 2003Mitosis exit
The mitosis-to-interphase transition involves dramatic cellular reorganization from a state that supports chromosome segregation to a state that complies with all functions of an interphase cell.
This process, termed mitotic exit, depends on the removal of mitotic phosphorylations from a broad range of substrates.
Mitotic exit regulation involves inactivation of mitotic kinases and activation of counteracting protein phosphatases.
The key mitotic exit phosphatase in budding (...)