Functional proteic groups

Articles

• chemokines
  18 November 2003

  Chemotactic cytokines

• HDACs
  23 November 2003

  histone deacetylases

• growth factor receptors
  21 November 2003

  References
  Leof EB. Growth factor receptor signalling: location, location, location. Trends Cell Biol. 2000 Aug;10(8):343-8. PMID: #10884687#

• oncogenes
  29 October 2003

  Pathology
  activation mutation
  overexpression
  fusion gene in which the promoter region of genes coding for the subunits of immunoglobulins (IGHG1, IGLC1, IGKC) or TCR (TCRA, TCRB, TCRC, TCRD) are juxtaposed to the entire coding sequence of a second gene that is subsequently overexpressed in lymphoid cells causing lymphomas or lymphoid leukemias
  fusion gene in which the promoter region of a first gene is juxtaposed to the entire coding sequence of a second gene that is subsequently (...)

• nuclear hormone receptors
  23 November 2003

  NHRs

• chaperonins
  23 November 2003

  Chaperonins are multisubunit, cylinder-shaped molecular chaperones involved in folding newly synthesized polypeptides.
  Chaperonins are key components of the cellular chaperone machinery. These large, cylindrical complexes contain a central cavity that binds to unfolded polypeptides and sequesters them from the cellular environment. Substrate folding then occurs in this central cavity in an ATP-dependent manner.
  The eukaryotic chaperonin TCP-1 ring complex (TRiC, also called CCT) is (...)

• anion transporters
  21 November 2003

  Pathology
  diastrophic dysplasia
  congenital chloride diarrhoea
  Pendred syndrome
  References
  Everett LA, Green ED. A family of mammalian anion transporters and their involvement in human genetic diseases. Hum Mol Genet. 1999;8(10):1883-91. PMID: #10469841#

• odorant receptors
  23 November 2003

  References
  Kratz E, Dugas JC, Ngai J. Odorant receptor gene regulation: implications from genomic organization. Trends Genet. 2002 Jan;18(1):29-34. PMID: #11750698#

• DNA methyltransferases
  21 November 2003

  Patterns of DNA methylation are laid out during early embryogenesis via the interplay of at least three active DNA methyltransferases, DNMT1, DNMT3A, and DNMT3B, and targeted deletions of these genes in the mouse have demonstrated that the enzymes are essential for normal development.
  DNMT1 associates with the DNA replication fork and functions as a hemi-methylase responsible for maintaining correct methylation patterns on DNA replication. DNMT3s (DNMT3A and DNMT3B) are instead de novo (...)

• protein phosphatases
  1 December 2003

  Mitosis exit
  The mitosis-to-interphase transition involves dramatic cellular reorganization from a state that supports chromosome segregation to a state that complies with all functions of an interphase cell.
  This process, termed mitotic exit, depends on the removal of mitotic phosphorylations from a broad range of substrates.
  Mitotic exit regulation involves inactivation of mitotic kinases and activation of counteracting protein phosphatases.
  The key mitotic exit phosphatase in budding (...)

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