A. Molecular pathology

• Arp2/3
  17 July

  Arp2/3 complex WKP
  Definition : Arp2/3 complex is a seven-subunit protein complex that plays a major role in the regulation of the actin cytoskeleton. It is a major component of the actin cytoskeleton and is found in most actin cytoskeleton-containing eukaryotic cells.
  Two of its subunits, the Actin-Related Proteins ARP2 and ARP3, closely resemble the structure of monomeric actin and serve as nucleation sites for new actin filaments.
  The complex binds to the sides of existing (...)

• GREB1
  10 July

  WKP
  Definition : Growth regulation by estrogen in breast cancer 1 is a protein that in humans is encoded by the GREB1 gene. This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
  Pathology
  GREB1-rearranged uterine sarcomas with variable (...)

• IL7
  13 June

  Definition : Interleukin 7 (IL-7) is a protein that in humans is encoded by the IL7 gene.
  IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by keratinocytes , dendritic cells , hepatocytes , neurons , and epithelial cells , but is not produced by normal lymphocytes.

• KITLG
  13 June

  SCF KITLG
  Definition : Stem cell factor (also known as SCF, KIT-ligand, KL, or steel factor) is a cytokine that binds to the c-KIT receptor (CD117). SCF can exist both as a transmembrane protein and a soluble protein. This cytokine plays an important role in hematopoiesis (formation of blood cells), spermatogenesis, and melanogenesis.

• GNA11
  13 June

  GNA11
  Guanine nucleotide-binding protein subunit alpha-11 is a protein that in humans is encoded by the GNA11 gene. Together with GNAQ (its paralogue), it functions as a Gq alpha subunit.
  Pathology
  GNA11 Mutation in Cutaneous Origin Melanoma (#26825879#)
  Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis. (#26778290#)
  High frequency of GNA14 , GNAQ , and GNA11 mutations in cherry hemangioma: a (...)

• GNA14
  13 June

  See also
  G proteins

• STING
  29 March

  STING protein

• LAMP2
  7 March

  WKP
  Definition : Lysosome-associated membrane protein 2 (LAMP2) also known as CD107b (Cluster of Differentiation 107b), is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins ( LAMPS ).
  The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the (...)

• CTHRC1
  23 February

  WKP
  Definition : Collagen triple helix repeat containing 1 is a protein that in humans is encoded by the CTHRC1 gene.
  The CTHRC1 protein may play a role in the cellular response to arterial injury through involvement in vascular remodeling.
  Pathology
  Collagen triple helix repeat containing 1 (CTHRC1) is overexpressed in different kinds of cancer tissues and may thus promote tumor formation.
  Mutations at this locus have been associated with Barrett esophagus and esophageal (...)

• STRN3
  7 January

  WKP
  Pathology
  NTRK3 fusion genes in fibrosarcomas (#30520818#) NTRK fusions in malignant tumors are therapeutic targets of tyrosine kinase inhibitors. CD34-positive fibrosarcoma of bone and soft tissue could be a good candidate for NTRK testing. STRN1-NTRK3 and STRN3-NTRK fusion genes

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