A. Molecular pathology

• IL7
  13 June

  Definition : Interleukin 7 (IL-7) is a protein that in humans is encoded by the IL7 gene.
  IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by keratinocytes , dendritic cells , hepatocytes , neurons , and epithelial cells , but is not produced by normal lymphocytes.

• KITLG
  13 June

  SCF KITLG
  Definition : Stem cell factor (also known as SCF, KIT-ligand, KL, or steel factor) is a cytokine that binds to the c-KIT receptor (CD117). SCF can exist both as a transmembrane protein and a soluble protein. This cytokine plays an important role in hematopoiesis (formation of blood cells), spermatogenesis, and melanogenesis.

• GNA11
  13 June

  GNA11
  Guanine nucleotide-binding protein subunit alpha-11 is a protein that in humans is encoded by the GNA11 gene. Together with GNAQ (its paralogue), it functions as a Gq alpha subunit.
  Pathology
  GNA11 Mutation in Cutaneous Origin Melanoma (#26825879#)
  Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis. (#26778290#)
  High frequency of GNA14 , GNAQ , and GNA11 mutations in cherry hemangioma: a (...)

• GNA14
  13 June

  See also
  G proteins

• STING
  29 March

  STING protein

• LAMP2
  7 March

  WKP
  Definition : Lysosome-associated membrane protein 2 (LAMP2) also known as CD107b (Cluster of Differentiation 107b), is a human gene. Its protein, LAMP2, is one of the lysosome-associated membrane glycoproteins ( LAMPS ).
  The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the (...)

• CTHRC1
  23 February

  WKP
  Definition : Collagen triple helix repeat containing 1 is a protein that in humans is encoded by the CTHRC1 gene.
  The CTHRC1 protein may play a role in the cellular response to arterial injury through involvement in vascular remodeling.
  Pathology
  Collagen triple helix repeat containing 1 (CTHRC1) is overexpressed in different kinds of cancer tissues and may thus promote tumor formation.
  Mutations at this locus have been associated with Barrett esophagus and esophageal (...)

• STRN3
  7 January

  WKP
  Pathology
  NTRK3 fusion genes in fibrosarcomas (#30520818#) NTRK fusions in malignant tumors are therapeutic targets of tyrosine kinase inhibitors. CD34-positive fibrosarcoma of bone and soft tissue could be a good candidate for NTRK testing. STRN1-NTRK3 and STRN3-NTRK fusion genes

• lipidome
  29 December 2018

  |WKP|
  Definition : The lipidome refers to the totality of lipids in cells. Lipids are one of the four major molecular components of biological organisms, along with proteins, sugars and nucleic acids.
  Lipidome is a term coined in the context of omics in modern biology, within the field of lipidomics.
  It can be studied using mass spectrometry and bioinformatics as well as traditional lab-based methods.
  The lipidome of a cell can be subdivided into the membrane-lipidome and (...)

• intakes
  29 December 2018

  Types
  lipid intakes
  glucid intakes
  protid intakes

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