NALP3 inflammasome
Members of the nucleotide-binding domain and leucine-rich repeat (LRR)-containing (NLR) family and the pyrin and HIN domain (PYHIN) family can form multiprotein complexes termed ’inflammasomes’.
The biochemical function of inflammasomes is to activate caspase-1, which leads to the maturation of interleukin 1 beta (IL-1β) and IL-18 and the induction of pyroptosis, a form of cell death.
Unlike other inflammasomes, the NLRP3 inflammasome can be activated by diverse stimuli. (...)
Home > D. General pathology > Blood and immunity
Blood and immunity
Hematologic disorders
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NLRP3 inflammasome
1 May -
mast cells
29 December 2018mastocyte WKP
Definition : A mast cell (also known as a mastocyte or formerly a labrocyte) is a type of white blood cell. Specifically, it is a type of granulocyte derived from the myeloid stem cell that is a part of the immune and neuroimmune systems and contains many granules rich in histamine and heparin.
Although best known for their role in allergy and anaphylaxis, mast cells play an important protective role as well, being intimately involved in wound healing, angiogenesis, (...) -
immunology
29 December 2018WKP
Definition : Immunology is a branch of biology, that covers the study of immune systems in all organisms.
Immunology charts, measures, and contextualizes the: physiological functioning of the immune system in states of both health and diseases.
Pathology
Malfunctions of the immune system in immunological disorders / immune diseases (such as autoimmune diseases , hypersensitivities , immune deficiencies , and transplant rejection.
The physical, chemical and physiological (...) -
non-self
29 December 2018WKP
The distinction of self from non-self is a central concept in immunology. -
self
29 December 2018WKP
See also
non-self
self-non-self model
Paywall references
Transplantation and identity: a dangerous split? Carosella ED, Pradeu T. Lancet. 2006 Jul 15;368(9531):183-4. PMID: #16844470# -
self-non-self model
29 December 2018https://en.wikipedia.org/wiki/Self
The self-non-self theory has dominated immunology since the 1950s.
See also
self
non-self
Open references
The danger theory: 20 years later. Pradeu T, Cooper EL. Front Immunol. 2012 Sep 17;3:287. doi:10.3389/fimmu.2012.00287. eCollection 2012. PMID: 23060876 -
immunosenescence
29 December 2018WKP
Definition : Immunosenescence refers to the gradual deterioration of the immune system brought on by natural age advancement. It involves both the host’s capacity to respond to infections and the development of long-term immune memory, especially by vaccination.
This age-associated immune deficiency is ubiquitous and found in both long- and short-living species as a function of their age relative to life expectancy rather than chronological time.
It is considered a major (...) -
danger theory
29 December 2018The self-non-self theory has dominated immunology since the 1950s. In the 1990s, Matzinger and her colleagues suggested a new, competing theory, called the "danger theory."
Authors assess the danger theory vis-à-vis recent experimental data on innate immunity, transplantation, cancers and tolerance to foreign entities, and try to elucidate more clearly whether danger is well defined.
Open references
The danger theory: 20 years later. Pradeu T, Cooper EL. Front Immunol. 2012 Sep 17;3:287. (...) -
immunological memory
29 December 2018Paywall references
Immunological memory: What’s in a name? Pradeu T, Du Pasquier L. Immunol Rev. 2018 May;283(1):7-20. doi:10.1111/imr.12652. PMID: #29664563# -
PFAPA
1 July 2017Periodic Fever Aphtous stomatitis Pharyngitis Adenitis; Mashall syndrome WKP
Definition : The periodic fever , aphthous stomatitis , pharyngitis and adenitis or periodic fever aphthous pharyngitis and cervical adenopathy (PFAPA) syndrome is a medical condition, typically starting in young children, in which high fever occurs periodically at intervals of about 3–5 weeks, frequently accompanied by aphthous-like ulcers, pharyngitis and/or cervical adenitis (cervical lymphadenopathy). The (...)
